Glutamate Receptors: Not Just for Excitation
نویسندگان
چکیده
منابع مشابه
Gustatory Receptors: Not Just for Good Taste
A recent study has found that a Drosophila gustatory receptor is required for thermotaxis. With other fly gustatory receptors having been shown to act in the detection of CO2, nutrients in the brain, and light, the roles of the so-called 'gustatory receptors' clearly go way beyond peripheral detection of non-volatile chemicals.
متن کاملBilirubin does not modulate ionotropic glutamate receptors or glutamate transporters.
Bilirubin, a product of haemoglobin metabolism, has been suggested to damage neurons by increasing activation of N-methyl-D-aspartate (NMDA) receptors when it reaches high levels in the blood [15,19], as occurs in neonatal jaundice [7]. Bilirubin is also generated in the brain following synthesis of the messenger carbon monoxide (CO) by haem oxygenase, and haem oxygenase is upregulated in Alzhe...
متن کاملExcitation of cerebellar interneurons by group I metabotropic glutamate receptors.
Cerebellar basket and stellate neurons (BSNs) provide feed-forward inhibition to Purkinje neurons (PNs) and thereby play a principal role in determining the output of the cerebellar cortex. During low-frequency transmission, glutamate released at parallel fiber synapses excites BSNs by binding to AMPA receptors; high-frequency transmission also recruits N-methyl-d-aspartate (NMDA) receptors. We...
متن کاملNeuronal nicotinic acetylcholine receptors: not just in brain.
THE REPORT from Fu et al., one of the current articles in focus (Ref 7, see page L1203 in this issue), shows the presence and functional activity of nicotinic acetylcholine receptors (nAChR) in neuroepithelial bodies (NEB) in neonatal hamster lung. NEB are small groups of pulmonary neuroendocrine cells (PNEC) located in airway epithelium typically at bifurcations of small airways. NEB appear to...
متن کاملMineralocorticoid receptors and cardiovascular damage: it's not just aldosterone.
Adecade before aldosterone was isolated and characterized, Hans Selye showed that administration of deoxycorticosterone acetate to rats sensitized by salt loading produced a vascular inflammatory response (polyarteritis) and tissue fibrosis. Fifty years later, Karl Weber and his colleagues showed that aldosterone and inappropriate salt intake produced cardiac hypertrophy and fibrosis1; this res...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Neuron
سال: 2019
ISSN: 0896-6273
DOI: 10.1016/j.neuron.2019.11.025